I've been using an immutable Linux for the last year or so, and it's gone quite well, but not without pain points.
There's a lot of stuff that I do which does not have a flatpak or package baked in. To get around this, I've been using distrobox to run these things in Ubuntu containers. So I will do "distrobox enter sdr" to have a terminal open up in that environment. You can export applications so that they show up in the applications list. It really takes some experience to shift your mindset, but it was worth it for me.
There's a lot of stuff that I do which does not have a flatpak or package baked in. To get around this, I've been using distrobox to run these things in Ubuntu containers. So I will do "distrobox enter sdr" to have a terminal open up in that environment. You can export applications so that they show up in the applications list. It really takes some experience to shift your mindset, but it was worth it for me.