The loss just on the lasers is 100x (i.e. delivered power is 1% of the input energy). Add in a combined cycle effeciency of only 50%, you're looking at needing a 200x improvement to have commercially relevant "net gain"
Yes but NIF's lasers date back to the 1990s, and laser technology has improved a lot since then. NIF-class lasers with over 20% efficiency are available now.