Chia is awesome for making pudding out of random liquids. I have to restrain myself from eating a batch of coconut milk cinnamon chia pudding in a single sitting.
Never going to advocate against eating whole foods if they taste good! But beware, the ALA omega 3 fat in flax and plant sources is not the DHA and EPA omega 3 fats used by animal cells, and so it's not as potent as what's in fish.
The main problem with ALA is that to have the good effects attributed to omega-3s, it must be converted by a limited supply of enzymes into EPA and DHA. As a result, only a small fraction of it has omega-3's effects — 10%–15%, maybe less. The remaining 85%–90% gets burned up as energy or metabolized in other ways. So in terms of omega-3 "power," a tablespoon of flaxseed oil is worth about 700 milligrams (mg) of EPA and DHA. That's still more than the 300 mg of EPA and DHA in many 1-gram fish oil capsules, but far less than what the 7 grams listed on the label might imply.
Also, beware of omega 6 fats. Seed oils (corn, soy, canola) used in commercial food products are incredibly omega 6 dominant in terms of polyunsaturated fat content. Consequently, the ratio of omega 3 to omega 6 fats we consume has plummeted as food production has industrialized. Omega 3 fats are precursors to generally anti-inflammatory signaling compounds, whereas omega 6 fats are precursors to pro-inflammatory signaling compounds. The bias in fat intake leads to more pro-inflammatory signaling in the body, and a lot of alt health types have alleged this is a major causative factor in the obesity epidemic.
This is important for depression, because chronic brain inflammation as a cause of depression was one of the going hypotheses at least a decade ago when I last looked into all of this. Upping omega 3 intake is an intervention that can address chronic inflammation, which is potentially why it improves some cases of depression.
Pretty much nobody in the west needs more omega 6s these days. I hear even farmed salmon eat primarily corn and soy based feeds these days, meaning their fat ratio is skewed much more heavily toward omega 6 than wild salmon and fish.
I have bad ADHD and printed the strangestloop.io blog post out and put it on the wall by my work desk in Oct 2023 according to the printout timestamp. I still haven't done the thing in some meaningful areas, and the print has honestly kind of been dispiriting. I'm going to take this post as the prompt to take it down.
I'm going to consider this with the same weight I would if my future grey-bearded self popped out of a portal to say it, thank you. I've had a sticky note on my monitor for a few years that just says "SHIP SHIP SHIP SHIP SHIP SHIP"; it might be time for that to go before it becomes much more depressing.
I'll add to my sibling commenters and say that there is a long history of critiquing the value of separation of concerns. One of my favorite early talks that sold me on React was "Pete Hunt: React: Rethinking best practices -- JSConf EU" from Oct 2013 [1] that critiqued the separation of concerns of HTML templates + JS popular in the 2000s and early 2010s and instead advocated for componentization as higher return on investment. I think people already saw styling separation of concerns as not particularly valuable at that point as well, just it wasn't clear what component-friendly styling abstraction was going to win.
I agree that we're responsible for what we create. I would also submit that corporate culture has been under intense selective pressure over the past 10 years to get good at creating compliance with ethically problematic software projects. I'm curious how many people left Google because they dropped the "don't be evil" motto.
There's lots of carrots (compensation, high quality desk jobs) and sticks (promotion structures, threat of offshoring). The really annoying and egregious aspects of corporate speak are easy targets for ire and take the heat, while the subtle euphemisms make the actual questionable projects easier to live with day to day.
This consideration reminds me of two other lines of research:
- Producing organisms with capable, healthy mitochondria requires mitonuclear compatibility (mitochondrial genome is from mother, nuclear genome is from both parents, energetic capacity and regulation requires both genomes to coordinate) and evidence is that organisms select highly for offspring that have higher mitonuclear compatibility and more capable mitochondria. Offspring that don't have capable enough mitochondria don't make it to term. For example, mammals are more permissive about mitonuclear compatibility than birds (who have extremely high energetic requirements) so mammals are more fecund, but we're also more likely to get cancer from inefficient mitochondria throwing off reactive oxygen species.
- Chris Palmer, a Harvard medical school MD psychiatrist, put out a book a few years ago hypothesizing most mental disorders as brain metabolic disorders — brain mitochondria problems. I've seen mixed reviews on the hypothesis (which I like) but it sure is interesting.
Taken together these imply: 1) some people get more energy than others at a biological level, 2) that impacts mental health, 3) there are interventions that can improve the energy baseline we each were given (as discussed in Palmer's book/talks).
I searched him up briefly, he's an advocate for the ketogenic diet for neural health. It's not surprising because medical grade keto can solve various nerve related issues such as epilepsy and may even be beneficial for childhood ADHD and Autism. He also advocates abstaining from substances which may harm brain and nervous system health, such as marijuana and alcohol. He also advocates for a holistic program of stress management, sleep and nutrient optimization.
Yep, i looked him up too. He has books and YouTube channel/videos on "Brain Energy" theory and "Metabolic Theory of Mental Illness" which seem to make a lot of sense.
The fundamental problem is that the "Modern World/Economy" has forced us to orient our Circadian Rhythms, Diet, Lifestyle etc. around its needs rather than the other way around. This makes absolutely no sense. We are what we Eat and are affected by our immediate Environment (both Natural and Societal). Thus the Organism cannot be separated from its Environment and all problems both Mental and Physical must have its roots in maladaptation. So any solution would have to be holistic starting with diet and lifestyle changes. This has been the basis for ancient systems of medicine like Ayurveda, Yoga etc. and yet most of us have forgotten these holistic approaches but instead look only at symptomatic treatment i.e. "popping pills" when things go wrong.
Shoutout to pyrsistent, a personal favorite library for frozen/immutable/hashable data structures whenever I need to use lists, sets, or dicts as dict keys, or make sets of such items: https://github.com/tobgu/pyrsistent
Break the aspects of language understanding and language generation apart. While I would agree that generative LLMs are understanding-free madlibs for writing text, embedding vector spaces and LLM latent spaces seem are a pretty genuine understanding of natural language. High dimensional vector spaces seem like the best machine representation we currently have for meaning and LLMs are using it effectively.
